Progress and perspectives of perioperative immunotherapy in non-small cell lung cancer

Progress and perspectives of perioperative immunotherapy in non-small cell lung cancer

Blog Article

Lung cancer is one of the leading causes of cancer-related death.Lung cancer mortality has decreased over the past decade, which is partly attributed to improved treatments.Curative surgery for patients with early-stage lung cancer is the standard of care, but not all surgical treatments have a good prognosis.

Adjuvant and neoadjuvant chemotherapy are used to improve the prognosis of patients with resectable lung cancer.Immunotherapy, an epoch-defining treatment, has improved Goblet Glasses curative effects, prognosis, and tolerability compared with traditional and ordinary cytotoxic chemotherapy, providing new hope for patients with non-small cell lung cancer (NSCLC).Immunotherapy-related clinical trials have reported encouraging clinical outcomes in their exploration of different types of perioperative immunotherapy, from neoadjuvant immune checkpoint inhibitor (ICI) monotherapy, neoadjuvant immune-combination therapy (chemoimmunotherapy, immunotherapy plus antiangiogenic therapy, immunotherapy plus radiotherapy, or concurrent chemoradiotherapy), adjuvant immunotherapy, and neoadjuvant combined adjuvant immunotherapy.

Phase 3 studies such as IMpower 010 and CheckMate 816 reported survival benefits of perioperative immunotherapy for Screw operable patients.This review summarizes up-to-date clinical studies and analyzes the efficiency and feasibility of different neoadjuvant therapies and biomarkers to identify optimal types of perioperative immunotherapy for NSCLC.